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Dynamic force sensing by bone delays aging and extends lifespan

Zhimin Zhang1, Zhiqing Cai2, Shencai Liu1

  • 1Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, Guangdong, China; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.

Cell Metabolism
|October 23, 2026
PubMed

Keywords:
PEDFPIEZO1agingbonebone marrowexercise mimeticsimmunosenescencelifespanmechano-sensingosteocytespigment epithelium-derived factor

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