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Supramolecular Peptide Assemblies Efficiently Catalyze the Retroaldol Reaction

Charitha J Abeygunawardena1, Liam R Marshall1, Ivan V Korendovych1

  • 1Department of Chemistry and Biochemistry, Baylor University, One Bear Place, Waco, Texas76798, United States.

Biochemistry
|October 23, 2026
PubMed

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Intramolecular aldol reaction occurs in dicarbonyl compounds such as dialdehydes, diketones, and keto-aldehydes. The dicarbonyl compounds possess more than one nucleophilic ⍺ carbon for the base to deprotonate and form the enolates. For example, in symmetrical diketones, there are four ⍺ carbons. Hence, four types of enolates are possible when treated with a base. However, since the molecule is symmetrical, the enolates formed on either side of one carbonyl group are equivalent to those formed...
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