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Updated: Oct 25, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Design, Synthesis, and Insecticidal Activity of Novel Fluorine-Containing Pyrazole Benzamide Derivatives
Wei Sun1, Xinyi Zhang1, Anjing Liao1
1State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang550025, China.
Abstract:
A series of fluorine-containing pyrazole benzamide derivatives were designed and synthesized. Compound Z1 exhibited significantly higher activity against P. xylostella (LC50 = 0.203 mg/L) than that of ethiprole (LC50 = 2.88 mg/L). Compounds Z1, Z8, and Z20 showed over 13-fold higher activity against S. frugiperda (LC50 = 3.38, 2.72, and 2.18 mg/L) than ethiprole (LC50 = 53.6 mg/L). Furthermore, compounds Z1, Z4, and Z20 exhibited good activity against O. furnacalis (LC50 = 4.21, 3.20, and 3.30 mg/L, respectively), with over 7-fold higher potency than ethiprole (LC50 = 30.8 mg/L). SAR analysis indicated that smaller substituents favored the insecticidal activity. MD simulations and ELISA confirmed that Z1 and tigolaner both target GABA receptors. Transcriptomic analysis further revealed that Z1 treatment disrupted motor protein and neuroactive ligand-receptor interaction pathways, upregulated ELOVL7 and SCD to remodel membrane lipids, and activated GST-mediated detoxification. These multipathway perturbations collectively underpin the insecticidal mechanism of Z1.
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