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Oral Small-Molecule GLP-1 Receptor Agonists: Lessons from Clinical Candidates and a Blueprint for Next-Generation

Jinrong Hu1, Yunfei Zhang1, Mengzhou Wang1

  • 1School of Biological and Pharmaceutical Sciences, Xi'an Key Laboratory for Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, Shaanxi University of Science & Technology, Xi'an710021, PR China.

Journal of Medicinal Chemistry
|October 23, 2026
PubMed

Keywords:
GLP-1Rallosteric modulationoral small-molecule agonistsorforglipronpeptidomimetic design

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