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Updated: Oct 25, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Selectfluor-Mediated Radical Cyclization of N-Arylbicyclo[1.1.0]butane-1-carboxamides with Diaryldiselenides
Yuze Lin1, Yina Liu1, Gang Yang1
1Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen361021, P. R. China.
Abstract:
Herein, we report a Selectfluor-mediated radical cascade cyclization of bicyclo[1.1.0]butanes (BCBs) with diaryl selenides through strain-promoted C-C σ-bond cleavage. This protocol provides a facile and efficient approach to selenium-decorated 3-spirocyclobutyl oxindoles in up to 99% yield for 30 examples. Moreover, the reaction is readily scalable to the gram scale, demonstrating its practical applicability. This protocol features a broad scope of substrate, peroxide-free, rapid, mild, and environmentally benign conditions, with excellent tolerance of broad functional groups.
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