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Updated: Oct 25, 2026

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Synthesis of Functionalized Cyanamide Derivatives Enabled by Hydrocyanamidation of Activated Alkenes or Alkynes
Hong-Ding Xie1, Xin-Yu Ding1, Li-Juan Sun2
1School of Chemistry and Chemical Engineering, University of South China, Hengyang421001, P. R. China.
Abstract:
The development of practical synthetic strategies for cyanamides remains a significant challenge. Here, we report a metal-free, fluoride-promoted hydrocyanamidation between readily accessible N-cyano-N-aryl-p-methylbenzenesulfonamide (NCTS) and activated alkenes or alkynes. This method features operational simplicity, a broad substrate scope, excellent functional group tolerance, and mild reaction conditions, offering a versatile approach to diverse disubstituted cyanamides. Furthermore, the practicality of this present method was evidenced by gram-scale synthesis and late-stage functionalization of the product.
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