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Updated: Oct 25, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Transition-Metal-Free Regioselective Construction of Cyano- and Phosphonyl Tetrazole Derivatives
Yufeng Wang1, Zeya Xu1, Ruiqi Liu1
1Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu273165, P. R. China.
Abstract:
A Brønsted base-promoted, transition-metal-free [3 + 2] cycloaddition for the regioselective synthesis of cyano- and phosphonyl-substituted tetrazoles is reported. Compared to readily decomposing diazonium salts, the use of arylazo sulfones not only enhances safety but also avoids the need for precious metal catalysts. Arylazo sulfones exhibit excellent reactivity, whereas other commonly used azo compounds are nearly ineffective. Modification of natural products, synthesis of dual tetrazoles, gram-scale reactions, and investigations into product transformation further highlight the promising applications.
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