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Updated: Oct 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Site-Selective C-H Arylation of Arenes: Using Diaryl Disulfides as an Arylation Reagent
Yunqi Liu1,2, Jiaqi Shan1, Yifan Xiao1
1State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou310058, P. R. China.
Abstract:
The development of site-selective C-H arylation of simple arenes is an urgent yet very challenging task. In particular, the meta-C-H activation of electron-deficient arenes is one of the most challenging substrates for selective functionalization and lacks efficient synthetic approaches. Herein, we address this long-standing challenge for the first time by using easily available diaryl disulfide as a new masked arylating reagent. Diaryl disulfide displays a broader scope of substrates and enables the promotion of the arylation of both electron-rich and electron-deficient arenes. The site selectivity of multisubstituted arenes can also be predictable from the well-understood electrophilic substitution-type (SEAr) mechanism.
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