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Updated: Oct 25, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Halogen Sources for the Controlled Dihalotrifluoroethoxylation and Dihalogenation of Alkynylsilanes in a
Haobo Jiang1, Hongxu Chen1, Xiaoqing Li1
1School of Environmental and Chemical Engineering, Wuyi University, Jiangmen529020, P.R. China.
Abstract:
We herein report the diiodotrifluoroethoxylation of alkynylsilanes with NH4I in a trifluoroethanol aqueous solution under mild conditions. This method enables a multicomponent one-pot reaction of diverse trifluoroethoxy-functionalized diiodoalkenes with high regio- and stereoselectivity. In addition, the resulting vicinal diiodinates are valuable in late-stage skeletal editing and in the discovery of new fluorescence materials. Moreover, dibromination and dichlorination, as well as the reaction mechanism, have also been investigated.
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