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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Platelet Diagnostics
Daniel Echelman1, Andrew L Frelinger2
1Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Abstract:
Abnormalities of platelet number and function are among the most common, and at times most vexing, consultations posed to the clinical hematologist. This article surveys the contemporary diagnostic approach to platelet disorders, progressing from the clinical history, examination, and first-line laboratory assessment, through the specialized phenotypic and functional assays used to characterize platelet reactivity, and finally to the molecular testing and emerging methods that are advancing in the field.
