The overlooked macrophages in adipose tissue

Adipose tissue macrophages (ATMs) are heterogeneous, with distinct roles in metabolism. Prior studies mainly used collagenase-based stromal vascular fraction isolation to study ATM heterogeneity. Hu et al. employed multiple approaches, including a revised collagenase-based protocol, to investigate 'adhesion-related macrophages', substantially advancing our understanding of this often-overlooked ATM subpopulation.