Related Experiment Videos
Respiratory support duration and the association between patent ductus arteriosus exposure and bronchopulmonary
Emel Okulu1, Omer Erdeve2, Zehra Arslan3
1Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Türkiye. emelokulu@gmail.com.
Objective:
To determine whether the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (BPD) differs according to the duration of invasive respiratory support in very preterm infants.
Study Design:
This secondary analysis of the multicenter, prospective INTERPDA cohort included infants born at <29 weeks' gestation with moderate-to-large PDA requiring respiratory support. Infants were stratified according to PDA exposure duration ( < 14 and ≥14 days) and cumulative invasive respiratory support duration ( < 10 and ≥10 days).
Results:
Among 363 infants, prolonged PDA exposure was associated with higher rates of moderate/severe BPD, BPD or death, and mortality only in infants requiring ≥10 days of respiratory support. In adjusted analyses, prolonged PDA exposure remained independently associated with these adverse outcomes.
Conclusion:
Prolonged PDA exposure was associated with adverse pulmonary outcomes primarily in infants with prolonged respiratory dependence, supporting an individualized, physiology-based approach to PDA management in very preterm infants.
Related Concept Videos
Pulmonary Cycle: Exhalation
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic Obstructive Pulmonary Disease I: Introduction
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...