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Updated: Oct 25, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
Disease trajectory in cerebral amyloid angiopathy: a matter of time
Marialuisa Zedde1,2, Vincenzo D'Agostino3, Francesca Romana Pezzella4,5
1Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, 42123, Italy. marialuisa.zedde@gmail.com.
Abstract:
Cerebral amyloid angiopathy (CAA) is a significant contributor to cerebrovascular disease, characterized by the deposition of amyloid-beta in the walls of cerebral small arteries and capillaries. This communication presents a detailed long-term follow-up of a 75-year-old female patient diagnosed with possible CAA in 2016, who demonstrated various clinical and neuroradiological manifestations over an 11-year period. Initial assessments revealed a right prerolandic hyperdense spontaneous convexal subarachnoid hemorrhage (cSAH) and a small vessel disease pattern on MRI. Subsequent imaging highlighted the progression of leptomeningeal involvement and cortical superficial siderosis (cSS), culminating in a lobar intracerebral hemorrhage (ICH) in 2026. This example shows the complexity and variability of CAA progression, underscoring different phenotypes and disease trajectories associated with CAA, and advocating for a nuanced understanding of its natural history to enhance personalized management strategies.
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