Efficacy of artificial intelligence-driven conversational agents (chatbots) for mental health promotion among...

University students experience substantial mental-health burdens, while access to timely support remains uneven. AI conversational agents may provide low-threshold support, but the evidence base has expanded rapidly and prior reviews have often combined different age groups, intervention types, outcome domains, and comparator conditions.

To evaluate the effects of AI-mediated conversational interventions on depressive and anxiety symptoms in university students, while distinguishing outcome domains, comparator intensity, intervention architecture, and the evidential requirements for standardized post-intervention effect estimation.

We updated the search in PubMed, Embase, PsycINFO, CENTRAL, and Web of Science to the revised search date and rebuilt an auditable cross-database record ledger. The updated workflow included 3,786 exported records, 451 DOI/PMID duplicates, 41 confirmed title/author duplicates, and 3,294 unique records screened. All title/abstract records completed a two-reviewer screening and consensus chain. Forty-six update-search records entered research-level/full-text assessment. Randomized controlled trials were eligible for causal quantitative synthesis; relevant feasibility, acceptability, usability, and non-comparable controlled studies were retained narratively. Standard post-intervention analyses used Hedges g, REML random-effects models, and Hartung-Knapp adjustment, and were restricted to attributable two-group post-intervention data.

In the final locked non-active/low-intensity comparator analysis, three depression comparisons favored conversational interventions (k=3; Hedges g=-0.413, 95% CI -0.557 to -0.268; I2 = 0.0%) and four anxiety comparisons also favored them (k=4; Hedges g=-0.435, 95% CI -0.603 to -0.268; I2 = 2.1%). In the separate active conversational-control analysis, two MYLO comparisons did not show a reliable incremental effect for depression (k=2; g=0.165, 95% CI -0.580 to 0.911) or anxiety (k=2; g=0.190, 95% CI -0.556 to 0.937). The evidence base remained small, clinically heterogeneous, and limited by attrition, self-reported outcomes, and uncertainty regarding generalizability.

AI conversational interventions may improve depressive and anxiety symptoms relative to non-active or low-intensity comparators in university students, but the certainty of evidence is low and estimates are based on few comparisons. Evidence against active conversational controls is very uncertain. Outcome-domain differences and architecture-related claims should be treated as hypothesis-generating. Secure, consent-based, human-supervised implementation and objective outcome assessment are priorities for future research.

https://www.crd.york.ac.uk/PROSPERO/view/CRD420261323382, identifier CRD420261323382.