Related Experiment Videos
The role of OSMRβ in inflammatory skin diseases
Qianqian Zhang1, Guifang Qin1, Xiaomin Huang1
1Department of Dermatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Abstract:
OSMRβ is a member of the IL-6 cytokine receptor family and plays a critical role in pruritus and immune-mediated skin diseases. Upon inflammatory stimulation, skin immune cells release OSM and IL-31. These cytokines signal through the heterodimeric receptor complexes OSMRβ/gp130 (type II OSM receptor) and OSMRβ/IL-31RA (IL-31 receptor), which are expressed on keratinocytes, fibroblasts, and dorsal root ganglion (DRG) neurons. Engagement of these receptors activates downstream JAK/STAT, MAPK/ERK and PI3K/AKT signaling cascades, leading to itch and inflammation that contributing to the pathogenesis of atopic dermatitis (AD), psoriasis (PSO), prurigo nodularis (PN) and familial primary localized cutaneous amyloidosis (FPLCA). Although a wide range of therapeutic options exist for these diseases, specific targeted treatments remain lacking. Vixarelimab, an OSMRβ-targeting monoclonal antibody, is currently under clinical evaluation for PN and AD.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Skin Microbiota
Inflammatory Bowel Disease II: Ulcerative Colitis
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
The JAK-STAT Signaling Pathway