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Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
05:50

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro

Published on: September 26, 2025

Structure-Based Design of New Nonpeptidic Covalent Mpro Inhibitors against SARS-CoV‑2 and Omicron Variants

Honglei Bao1, Lingchen Sun2, Shilin Gong1

  • 1Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao 999078, China.

ACS Bio & Med Chem Au
|October 24, 2026
PubMed

Keywords:
COVID-19 treatmentOmicron variantsSARS-CoV-2covalent inhibitorsdeuterated drugmain proteasestructure-based drug design

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