Short Term Effect on the Ocular Surface of a Liposome-Based Eye Spray in Dry Eye Disease

Spray-based formulations have been proposed as an alternative approach for ocular surface treatment, particularly to improve ease of administration. However, limited data are available regarding their ability to reach and persist on the ocular surface when applied to closed eyelids.

This prospective, single-center study evaluated the presence and short-term persistence on the ocular surface of a liposome-based periocular spray in patients with dry eye disease. A total of 20 patients (40 eyes) were included. Tear film parameters were assessed using the Keratograph® 5M at baseline and at 15, 30, and 60 minutes after spray application. Outcome measures included non-invasive Keratograph break-up time (NIKBUT), tear meniscus height, bulbar conjunctival redness and patient-reported ocular discomfort.

NIKBUT values showed a significant increase at all post-application time points compared with baseline (p < 0.05), indicating improved tear film stability. Tear meniscus height exhibited a transient increase at 15 minutes (p < 0.05), returning toward baseline thereafter. No significant changes were observed in bulbar conjunctival redness. Subjective ocular discomfort scores significantly decreased following spray application (p < 0.05). No adverse events were reported.

Periocular application of a liposome-based spray on closed eyelids resulted in measurable short-term improvements in tear film stability and patient-reported symptoms without inducing ocular surface irritation. These findings support the ability of this administration route to deliver functional effects on the ocular surface in patients with dry eye disease.