Related Experiment Videos
Medication-related osteonecrosis of the jaw: Current concepts in epidemiology, pathophysiology, diagnosis, and
Oskar Łodygowski1, Bartłomiej Antoń2, Marcin Kozakiewicz1
1MEDICAL UNIVERSITY OF LODZ, LODZ, POLAND.
Objective:
Aim: The aim of this review was to highlight the ongoing challenge of medication-related osteonecrosis of the jaw (MRONJ) in everyday clinical practice.
Patients And Methods:
Materials and Methods: This review was conducted following a structured narrative approach, utilizing PubMed as the primary research database. The following keywords and their combinations with Boolean operators (AND, OR) were used: MRONJ, osteonecrosis, bisphosphonates, bone density conservation agents, denosumab. The literature search spanned publications from 2003 to April 2025, corresponding to the first description of bisphosphonate-related osteonecrosis of the jaw by Marx and subsequent evolution of the diagnostic and therapeutic concepts.The final set of 32 articles were reviewed and synthesized narratively.
Conclusion:
Conclusions: Management strategies are examined across disease stages, from conservative measures and pharmacologic interventions to surgical resection and reconstruction. Emerging therapies, including teriparatide, hyperbaric oxygen, platelet-rich preparations, and cryosurgery, show promise as adjunctive treatments. Prevention remains paramount, emphasizing pre-treatment dental evaluation, patient education, and interprofessional collaboration.
Related Concept Videos
Osteoclasts in Bone Remodeling
Endocarditis III: Medical Management
Rheumatic Heart Disease III: Medical Management
Rheumatic Heart Disease IV: Nursing Management
Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.