Related Experiment Videos
MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes
Zongwei Lu1, Junhao Ma1, Jinpeng Yang1
1State Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, P. R. China.
Abstract:
Membrane proteins (MPs) are vital drug targets, yet existing resources are fragmented across structural, pharmacological, and disease domains, limiting integrated exploration. To address this, we developed the Membrane Protein-Drug-Disease (MPDD) Database (https://chemyang.ccnu.edu.cn/ccb/server/MPDD/), a curated platform explicitly linking MPs, drugs, and diseases. MPDD currently includes 1523 MP targets, 589 diseases, and 18,489 drugs. It offers multi-dimensional query tools, interactive classification trees, drug property analysis, BLAST search, and co-target network visualization. By unifying the MP-drug-disease triad, MPDD aims to accelerate mechanistic studies, druggability evaluation, and targeted therapy discovery.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Drug Discovery: Overview
Primary Active Transport
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
The Significance of Membrane Transport
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...