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Updated: Oct 26, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
(±)-Nigronetides A-D and Nigronetides E-H, Complex Polyketides Produced by the Marine-Derived Fungus Nigrograna sp.
Marcelo R de Amorim1, Andres F T Peña1, Tiago A Paz2
1Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo13560-970, Brazil.
Abstract:
(±)-Nigronetides A-D (1-4) and nigronetides E-H (5-8), polyketides with complex carbon skeletons, were isolated from cultures of the marine-derived fungus Nigrograna sp. M13, presenting three novel carbon skeletons. While the planar structures and relative configuration of (±)-nigronetides A-D (1-4) were established by analysis of spectroscopic data, the absolute configuration of nigronetides E-H (5-8) was assigned using a combination of analysis of NOESY data, quantum chemical NMR calculations, as well as by comparison between experimental and calculated electronic circular dichroism (ECD) spectra. (±)-Nigronetides A-D (1-4) were isolated as scalemic mixtures of an almost identical ratio between enantiomers. Compounds 1-8 were inactive in antiplasmodial assays against the Plasmodium falciparum 3D7 strain as well as in cytotoxicity assays against several cancer cell lines.
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