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Published on: November 2, 2016
Total Synthesis of the Cyclodepsipeptide Nodupetide and Evaluation of Its Cytotoxicity
Siva Ramakrishna Paipuri1,2, Kavya Lekha Sunkara2,3, Sunil Misra2,3
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad500007, Telangana, India.
Abstract:
The stereoselective total synthesis of the cyclodepsipeptide nodupetide (1) with a 3-hydroxy-4-methylhexanoic acid (HMHA) moiety is described. Evan's aldol approach for fixing the chirality in the HMHA motif and classical liquid-phase peptide coupling procedures for construction of the tetrapeptide were utilized. Preliminary biological evaluation of the synthesized natural product along with its two acyclic precursors indicated cytotoxic activities.
