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Updated: Oct 26, 2026
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Temporal trends of treatment and mortality in small renal masses <2cm
Michele Nicolazzini1, Calogero Catanzaro2, Federico Polverino3
1Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy; Division of Urology, Department of Oncology, University of Turin, Turin, Italy.
Objective:
To explore contemporary rates and temporal trends of Guidelines-recommended management options for small renal masses (SRM)<2cm, that include non-interventional management (NIM), local tumor destruction (LTD) and nephrectomy (either partial -PN- or radical -RN).
Methods:
Within the SEER database (2004-2022), SRM<2cm patients were identified and stratified according to four examined management options. Estimated annual percentage change (EAPC) were tabulated according to management type. Five-years cancer-specific mortality (CSM) rates were computed. Multivariable logistic regression tested predictors of NIM, LTD and RN.
Results:
Of 20,769 SRM<2cm patients, 12,107 (58.3%) underwent PN vs. 3,558 (17.1%) NIM vs. 2,879 (13.9%) RN vs. 2,225 (10.7%) LTD. During the study span, NIM rates increased from 8.0% in 2004 to 23.9% in 2022 (EAPC+5.1%, p<0.001). The increase in NIM rates was more pronounced in patients aged ≥70 years (from 22.0% to 45.9%, ∆+23.9, EAPC +3.3%, p<0.001). and in African American (from 4.5% to 23.2%, ∆+18.7, EAPC +5.0%, p<0.001). At multivariable logistic regression models age ≥70 years (OR 9.24, p<0.001) and African American race (OR 1.39, p<0.001) independently predicted NIM. Five-years CSM remained stable over the study span: 2.8% in 2004 and 2.9% in 2017 (EAPC -1.0%, p=0.4).
Conclusion:
In SRM<2cm patients, rates of NIM are very low, even in the most recent study years. However, NIM rates increased overtime across all sex, age and race categories, with most pronounced increase among elderly and African American. Concurrently, five-years CSM rates have not increased despite the wider adoption of NIM.
