Perioperative Spinal Cord Stimulation Combined With Targeted Muscle Reinnervation for Chronic Neuropathic Pain: A...

Phantom limb pain (PLP) and residual limb pain (RLP) are often difficult to treat with pharmacologic regimen alone and affect many lower extremity amputation patients. We report the case of a 56-year-old female patient with chronic PLP and a right above-the-knee amputation who underwent perioperative spinal cord stimulation (SCS) in conjunction with targeted nerve reinnervation. Following SCS implantation and surgical intervention, the patient reported sustained significant pain reduction of approximately 80% over three months, improved function, and cessation of analgesic use. This case illustrates the feasibility of sequential central neuromodulation and peripheral nerve reconstruction in refractory post-amputation pain and generates the hypothesis that these approaches may have complementary roles.