Copper and cobalt complexes with famotidine
MacKenzie C Weaver1, Allen G Oliver2, Toni L O Barstis1
1Department of Chemistry and Physics, Saint Mary's College, Notre Dame, IN 46556, USA.
Abstract:
This research contributes to the development of Paper-Based Analytical Devices (PADs) for screening low-quality famotidine, the active pharmaceutical ingredient in Pepcid AC. While three key colorimetric chemical tests - copper(II) sulfate, cobalt(II) thiocyanate, and nickel(II) chloride - are employed on these PADs, the underlying chemistry remains poorly understood. Here we report the successful isolation and structural characterization of two new crystalline colored famotidine-metal complexes generated during PAD activation. These are a green-colored famotidine-copper(II) chloride complex, (3-{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}-N-sulfamoylpropanamide)dichloridocopper(II), [CuCl2(C8H14N6O3S3)], and a blue-colored famotidine propionic acid-cobalt(II) tetrachloride complex, bis(4-{[(2-carboxyethyl)sulfanyl]methyl}-N-(diaminomethylidene)-1,3-thiazol-2-aminium) tetrachloridocobaltate(II), (C8H13N4O2S2)2[CoCl4]. Elucidating these crystal structures provides critical insights into the chemistry occurring on the activated PADs, enabling further device development and optimization.
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