Probable cychlorphine exposure in a patient with opioid use disorder: A case report

Cychlorphine is an emerging synthetic opioid with limited clinical data.

We describe a patient's reported cychlorphine use and its's clinical effects.

Thirty-five years old male with opioid use disorder reported purchasing cychlorphine online. He described marked sedation and respiratory depression. Standard toxicology did not detect cychlorphine. Patient died 2 months later from a drug poisoning event.

Clinicians should ask about online drug purchases and manage suspected opioid intoxication based on clinical symptoms.

This case highlights the risk associated with emerging NSOs, the limitations of standard and even sophisticated toxicology screening.