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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
Abstract:
The antibody-drug conjugate field is increasingly looking to go after more than one target at a time. Preliminary efficacy data suggest that B7-H3-targeting elfetabart drozuntecan plus the PD-L1-VEGF-A bispecific pumitamig could be a potential combination strategy. As well, two bispecific ADCs, respectively targeting EGFR-c-MET and EGFR-B7-H3, appear active against multiple solid tumor types.