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Updated: Oct 28, 2026

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
Published on: January 31, 2025
Rethinking kidney cancer through the lens of microphthalmia (MiT)/transcription factor E (TFE) Biology
1Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy.
Abstract:
Microphthalmia/transcription factor E (MiT/TFE) transcription factors are central regulators of lysosomal function, mechanistic target of rapamycin complex 1 (mTORC1) signaling, and cellular metabolism, and their dysregulation is increasingly recognized as a key driver of kidney cancer. This forum provides an overview of the molecular mechanisms underlying MiT/TFE-associated renal tumorigenesis and discusses their implications for cancer biology and therapy.
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