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Updated: Oct 28, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
[Hybrid myocardial revascularization in elderly and senile patients: Advantages and disadvantages.]
S S Mikhailov1,2, A N Shishkevich1,2, V N Kravchuk2
1S.M.Kirov Military Medical Academy, 6 lit. Zh Academician Lebedev str., St. Petersburg 194044, Russian Federation,
Abstract:
Hybrid coronary revascularization (HCR) is a strategy combining minimally invasive left internal mammary artery to left anterior descending artery bypass grafting with percutaneous coronary intervention of the remaining vessels. This approach is of particular relevance in elderly (60-74 years) and senile (≥75 years) patients due to high surgical risk and severe comorbidities. This review analyzes current evidence (2016-2025) on the efficacy and safety of HCR in this population. HCR provides long-term survival comparable to conventional coronary artery bypass grafting with lower perioperative trauma, shorter hospital stay, and reduced neurological complications. Key limitations include the need for dual antiplatelet therapy, higher mid-term repeat revascularization rates, technical complexity, and resource intensity. Decisions regarding HCR in elderly patients require thorough multidisciplinary assessment including frailty screening, functional status, and life expectancy evaluation.
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