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Updated: Oct 28, 2026
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
[Role of immune inhibitory checkpoint-molecules PD-1 and TIM-3 in neurodegenerative pathology (analytical review).]
O S Anikeeva1, E V Markova1, I A Goldina1
1Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya str., Novosibirsk 630099, Russian Federation,
Abstract:
Immune inhibitory checkpoint-molecules play an important role in maintaining immune homeostasis by preventing excessive activation of the immune system. Neurodegenerative diseases are characterized by chronic neuroinflammation, in which T-cell and microglial dysfunction play a key role. This review presents an analysis of current literature demonstrating the role of the immune checkpoint-molecules in the pathogenesis and potential treatment of neurodegenerative diseases.