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Published on: December 2, 2014
Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery
Tomoyuki Shiozawa1, Tomoyasu Kadoguchi2,3, Hyeon-Cheol Lee-Okada4
1Department of Cardiovascular Medicine, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
Abstract:
Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography-mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.
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