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Updated: Oct 28, 2026

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
Published on: November 30, 2018
Systemic fibrinogen Aα-chain amyloidosis in 3 Japanese raccoon dogs
Momoko Yoshikura1, Natsumi Kobayashi1, Mitsuhiro Ikeda2
1Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Abstract:
Systemic fibrinogen Aα-chain (FibA) amyloidosis-in which amyloid is deposited in renal glomeruli and the heart-has been reported in humans, Japanese squirrels, and dogs. Here, we describe systemic FibA amyloidosis in 3 aged Japanese raccoon dogs (Nyctereutes procyonoides viverrinus). Histologically, we observed marked deposits of amyloid in the renal glomeruli and cardiac arterial walls. Liquid chromatography-tandem mass spectrometry-based proteomic analysis of the amyloid deposits, together with immunohistochemistry, identified the αC-domain of FibA as the major component of the amyloid. Given that all affected individuals were aged (>12-y-old) and genetic analysis revealed no amino acid mutations in FibA, aging may have contributed to disease development. The deposition of αC-domain-derived FibA amyloid in the renal glomeruli and heart in Japanese raccoon dogs resembles that reported in Japanese squirrels and dogs, suggesting a conserved pathogenic mechanism across species.
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