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Updated: Oct 28, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Tertiary Lymphoid Structures in Non-Muscle-Invasive Bladder Cancer: Quality over Quantity
Ali Ghasemzadeh1, Eugene J Pietzak1
1Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
High tertiary lymphoid structure (TLS) density predicts favorable outcomes in several solid tumors but worse outcomes in bladder cancer, and the basis for this discrepancy is unclear. In this issue, Péricart and colleagues leverage en bloc resection of non-muscle-invasive bladder tumors to show that TLS accumulate without acquiring the features of productive antitumor immunity. The work reframes TLS in this setting as structures for which functional state, not abundance, dictates their contribution to tumor control. See related article by Péricart et al., p. XX.
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