Antioxidant Activity of a New Series of Carbazole-Derived Nitrones
Maciej J Rojewski1, Dimitra Hadjipavlou-Litina2, Iwona E Głowacka1
1Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego, 90-151 Lodz, Poland.
Abstract:
A new series of 2- and 4-substituted carbazole-derived nitrones was synthesized and evaluated for their antioxidant properties using multiple in vitro protocols, including inhibition of AAPH-induced lipid peroxidation, hydroxyl radical scavenging, ABTS•+-decolorization and DPPH interaction assays. Their anti-inflammatory capacity was investigated through the inhibition of soybean lipoxygenase (SLOX). Among all fourteen tested nitrones, compound 11bg emerged as the most promising derivative, exhibiting strong inhibition of lipid peroxidation and efficient hydroxyl radical scavenging activity. Nitrone 11be showed the highest lipoxygenase inhibition with an IC50 value of 0.0225 μM. Furthermore, seven of the fourteen synthesized hybrids showed strong SLOX inhibitory activity, with IC50 values below 30 μM.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
07:38A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Related Concept Videos
Nitrosation of Enols
2° Amines to N-Nitrosamines: Reaction with NaNO2
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H
Electrophilic Aromatic Substitution: Nitration of Benzene
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
