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Apoptosis: The dual roles it plays during PRRSV infection
1Institute of Veterinary Immunology and Green Drugs, Veterinary Department in College of Animal Science, State Key Laboratory of Green Pesticide, Guizhou University, Guiyang, 550025, China.
Abstract:
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious swine virus that endangers pig breeding due to its rapid mutation and global distribution. Currently, the lack of effective drugs and vaccines makes the prevention and treatment of PRRSV particularly difficult. During infection, apoptosis acts as a critical regulatory hub, influencing the infection process through various mechanisms. This review examines how viruses exploit apoptotic responses to facilitate viral replication and how host cells can inhibit viral growth by inducing apoptosis. Additionally, we examine how antiviral agents target apoptotic pathways. These insights are crucial for understanding the virus's infection strategy and for developing improved antiviral treatments and targets.
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