Related Experiment Videos
Evaluating Macrolide Challenge-Confirmed Cross-reactivity in Children: A Single-Centre Retrospective Case Series
Duaa Gaafar1, Noel Cranswick1, John Christodoulou2
1Infectious Diseases, Clinical Pharmacology and Allergy & Immunology, Department of General Medicine, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia; Murdoch Children's Research Institute, Parkville, Australia.
The Journal of Allergy and Clinical Immunology. in Practice
|October 27, 2026
Abstract
Clinical Implications:
Confirmed allergy to one macrolide rarely precludes use of another. In this paediatric series, all eight challenged children tolerated an alternative macrolide, supporting case-by-case oral challenge over class-wide avoidance.
Related Concept Videos
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...