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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Emerging Role of Activated T cells in Pediatric Acute Liver Failure
Harry Sutton1, Tamir Diamond2, Catherine A Chapin3
1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Temerity Faculty of Medicine of University of Toronto, Toronto Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.
Abstract:
Activated T-cell hepatitis (TC-Hep) is an immune-mediated liver disease that presents in children aged 1 to 17 years with jaundice and high aminotransferases; severity ranges from severe hepatitis to acute liver failure (ALF). Many children previously labeled indeterminate ALF can be reclassified as TC-Hep. TC-Hep patients have liver tissue with diffuse portal and lobular CD8 T-cell inflammation and peripheral blood markers of T-cell activation. Treatment includes supportive care and consideration of immunosuppression, with optimal regimens yet to be determined. TC-Hep is not a chronic or recurrent disease, but patients are at a uniquely increased risk of developing aplastic anemia.
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