Construction and validation of a unified 3D convolutional neural network framework for automated identification of...

To construct and validate a standardized three-dimensional convolutional neural network (3D CNN) framework based on cervical spine CT imaging for automated identification of cervical spinal cord injury (CSCI), and to evaluate its stability across multicenter data and potential clinical applicability.

Cervical spine CT images were retrospectively collected from two independent clinical centers, including cases with and without cervical spinal cord injury. All images were converted to NIfTI format through a unified preprocessing pipeline, and three-dimensional spinal cord regions of interest (ROIs) were delineated using ITK-SNAP to assess interobserver consistency. A standardized 3D CNN architecture was constructed, and the dataset was divided into training, internal validation, and external validation sets using a stratified random strategy. Model training was performed using the PyTorch framework. Classification performance across different datasets was systematically evaluated, and ROC curves, precision-recall (PR) curves, prediction probability distributions, and threshold sensitivity analyses were used to explore the model's clinical application characteristics.

The model demonstrated stable discriminative performance across the training, internal validation, and external validation sets, with AUC-ROC values of 0.943, 0.953, and 0.948, respectively, and AUC-PR values of 0.936, 0.939, and 0.943, respectively. Performance metrics showed minimal variation among datasets, with no evident overfitting or performance degradation. Prediction probability distributions indicated good separation between injured and non-injured samples. Threshold sensitivity analysis showed that the model could achieve performance trade-offs under different threshold settings, suggesting a degree of flexibility for clinical decision-making.

Based on standardized data processing and network design, the 3D CNN effectively extracted latent spatial information associated with cervical spinal cord injury from CT images. The proposed framework demonstrated good stability and reproducibility across multicenter data and may serve as a preliminary research framework for CT-based CSCI risk evaluation, particularly in scenarios where MRI is unavailable or limited. Prospective validation is required before clinical deployment. It also provides a methodological reference for the standardized construction of deep learning models in medical imaging research.