Related Experiment Video
Updated: Oct 29, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Primary Prostatic Diffuse Large B-Cell Lymphoma Mimicking Prostate Cancer With a Normal Prostate-Specific Antigen
Kota Amamoto1, Yuichiro Nakamura1, Hajime Fukushima1
1Department of Urology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.
Introduction:
Primary prostatic lymphoma is rare and may mimic prostate cancer clinically and radiologically.
Case Presentation:
A 66-year-old man was referred for evaluation of suspected advanced prostate cancer. Despite a normal prostate-specific antigen level of 0.573 ng/mL, imaging revealed a prostatic mass with suspected bladder invasion and bilateral hydronephrosis. Prostate needle biopsy showed atypical lymphocytic infiltration but could not distinguish lymphoma from inflammatory changes. Additional transurethral biopsy provided sufficient tissue for histopathological and immunohistochemical evaluation, establishing a diagnosis of primary prostatic diffuse large B-cell lymphoma.
Conclusion:
Primary prostatic lymphoma should be considered when clinical and imaging findings suggest prostate cancer despite a normal prostate-specific antigen level. Additional tissue sampling should be considered when needle biopsy is inconclusive despite persistent clinical suspicion of lymphoma.
