Recurrent Cellulitis in Lymphedema: Integrating Antibiotic Prophylaxis, Conservative Therapy, Local Disease Control,...

Recurrent cellulitis is a disabling complication of lymphedema, causing repeated antibiotic exposure, hospitalization, anxiety, activity restriction, and worsening edema. Although compression, skin care, early treatment, and antibiotic prophylaxis are established, recurrence may persist when lymphatic dysfunction, lymphorrhea, occult entry portals, or local lymphatic lesions remain unaddressed. This narrative review reframes recurrent cellulitis as chronic lymphatic vulnerability and proposes an integrated prevention framework.

English-language literature from April 2000 to March 2026 was reviewed using PubMed/MEDLINE, reference lists, consensus documents, and clinical guidelines. Evidence was synthesized narratively across pathophysiology, conservative care, antibiotic prophylaxis, local disease control, lymphatic imaging, lymphaticovenular anastomosis (LVA), and patient education. No quantitative pooling was performed.

Compression therapy reduced recurrent cellulitis from 40% to 15% in chronic leg edema, supporting edema control as infection prevention. Antibiotic prophylaxis can reduce recurrence during active treatment but does not correct lymphatic stasis, skin-barrier failure, lymphorrhea, or persistent portals of entry. LVA reduced cellulitis from 1.46 to 0.18 episodes per year in one clinical study, and randomized evidence supports LVA combined with conservative therapy. Local excision combined with genital or lower-limb LVA reduced cellulitis from 2.8 to 0.31 episodes per year in patients with genital lymphatic vesicles.

Durable prevention requires coordinated use of conservative care, antibiotic stabilization, local disease control, lymphatic imaging, selective LVA, and patient education. This multidisciplinary framework may help reduce recurrent febrile cellulitis while supporting safer antibiotic discontinuation, activity, confidence, and quality of life.