Augmentation of Dural Repair Using Absorbable Collagen Matrix After Spinal Tumor Resection
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Published on: May 26, 2026
Masaki Saito1, Akira Honda, Tomoki Nakajima
1Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Study Design:
Retrospective comparative study.
Objective:
To evaluate the effectiveness of an absorbable collagen matrix (DuraGen) in reducing postoperative cerebrospinal fluid (CSF) hypovolemia-related symptoms after intradural extramedullary spinal tumor resection.
Summary Of Background Data:
CSF leakage and related symptoms are frequent complications after intradural tumor surgery. Although various adjuncts are used for watertight dural closure, their efficacy remains uncertain. The collagen matrix has shown benefits in cranial surgery, but evidence in spinal surgery is limited.
Materials And Methods:
Twenty-four patients who underwent spinal tumor resection between February 2023 and April 2025 were retrospectively reviewed. Twelve underwent conventional dural repair with autologous fat, fibrin glue, and PGA mesh, and 12 underwent collagen matrix augmentation. Clinical variables, drain output, and postoperative CSF hypovolemia-related symptoms were analyzed.
Results:
The collagen matrix group had a significantly lower incidence of CSF hypovolemia-related symptoms than the conventional group (8% vs. 58%, P=0.009). Drain output on postoperative days 1 and 2 did not differ, but serosanguineous drainage was more frequent in the collagen matrix group (P=0.004).
Conclusions:
Collagen matrix augmentation significantly reduced CSF hypovolemia-related symptoms after spinal tumor resection without increasing operative time or blood loss. It may serve as a valuable adjunct for watertight dural closure and improved patient outcomes.
