Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased estrogen production in obese men.

G Schneider, M A Kirschner, R Berkowitz

    The Journal of Clinical Endocrinology and Metabolism
    |April 1, 1979
    PubMed
    Summary

    Morbidly obese men have elevated estrogen levels and production rates, despite lower testosterone. Their hormonal axes remain intact, suggesting potential estrogen receptor defects contributing to altered hormone metabolism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes.

    Journal of molecular biology·1999
    Same author

    Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center.

    Journal of molecular biology·1999
    Same author

    [Psychogenic impairment and current feelings in the elderly. Which options are offered by the biographical perspective?].

    Psychotherapie, Psychosomatik, medizinische Psychologie·1999
    Same author

    Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.

    Science (New York, N.Y.)·1999
    Same author

    [Soft tissue tumors. II].

    Der Radiologe·1999
    Same author

    [Soft tissue tumors. I. Classification and staging].

    Der Radiologe·1999

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Men's Health

    Background:

    • Obesity is associated with significant hormonal alterations.
    • Understanding the impact of obesity on sex hormone metabolism is crucial for men's health.

    Purpose of the Study:

    • To investigate serum and urinary estrogen and testosterone levels in morbidly obese men.
    • To assess the hypothalamic-pituitary-gonadal axis function and hormone conversion rates in obese men.

    Main Methods:

    • Measurement of serum estrone (E1), 17beta-estradiol (E2), and testosterone (T).
    • Assessment of urinary E1 and E2 production rates.
    • Evaluation of T clearance and conversion rates, and response to clomiphene citrate.

    Main Results:

    • Obese men showed 2-fold elevated serum E1 and E2, with increased urinary production rates.
    • Serum T was reduced, but free T concentrations remained normal due to elevated dialyzable fractions.
    • Increased metabolic clearance rates of T and peripheral conversion of androgens to estrogens were observed.

    Conclusions:

    • Obese men exhibit increased estrogen levels and production without signs of feminization or suppressed gonadotropins.
    • Intact hypothalamic-pituitary-Leydig cell axes were confirmed.
    • Defective estrogen receptors are postulated, leading to altered hormone binding, clearance, and production.

    Related Experiment Videos