Posterior Segment Herpes Simplex Virus-2 Ocular Disease in Children: A Case Series
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Updated: Oct 30, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
Geraldine Huynh1, Catherine Burton1, David Kimberlin2
1From the Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Abstract:
Five pediatric patients not known to be immunocompromised developed severe posterior segment herpes simplex virus-2 ocular disease at a median age of 13 years. Presentations mimicked noninfectious uveitis, optic neuritis, vasculitis and necrotizing retinitis, often delaying diagnosis. Intraocular polymerase chain reaction confirmed herpes simplex virus-2 in 4. Visual morbidity, retinal detachment and the requirement for surgical intervention were common, supporting early polymerase chain reaction testing, antiviral therapy and surveillance.
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