Qualitative study reveals perceived barriers and facilitators of preregistration in animal research

Preregistration-the prospective registration of hypotheses, methods and analyses plans-is a promising tool in promoting transparency, rigour and reproducibility in science. However, its adoption remains low, particularly in animal research, and little is known about factors influencing its uptake. We explored researchers' experiences and views on preregistration, identifying perceived facilitators and barriers, and gathering suggestions to improve its use. Within a larger cross-sectional mixed-methods project, semi-structured interviews were conducted with 30 Swiss-based researchers involved in animal research and thematically analysed independently by two researchers. Preregistration was described as uncommon in animal research, with views varying by prior experience. Researchers with preregistration experience reported more positive views, whereas those without were more critical. Main barriers included administrative burden, time constraints, limited flexibility and perceived incompatibility with exploratory research. Reported benefits comprised improved study planning, adherence to good research practices and increased transparency. Suggestions to improve uptake involved training, institutional support, integration with the existing authorization procedure and maintaining voluntary participation. Preregistration in animal research remains uncommon and is shaped by prior experience. Addressing barriers through training, institutional support and structural integration may broaden its adoption.