Related Experiment Video

Updated: Sep 24, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Septicemia caused by DF-2

D Schlossberg

    Journal of Clinical Microbiology
    |February 1, 1979
    PubMed

    Insights

    A rare gram-negative rod caused fatal septicemia in an alcoholic patient. This organism, similar to Pasturella multocida, is linked to dog bites and responds to penicillin treatment.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases

    Background:

    • Septicemia is a life-threatening bloodstream infection.
    • Gram-negative bacterial infections pose significant clinical challenges.

    Observation:

    • A 60-year-old male with a history of alcoholism developed fatal septicemia.
    • The causative agent was an unidentified gram-negative rod, rarely reported in literature.

    Findings:

    • The unidentified organism shares characteristics with Pasturella multocida.
    • Key similarities include being gram-negative and sensitive to penicillin.
    • A potential link to dog bites was noted for this rare pathogen.

    Implications:

    • Highlights the importance of identifying rare bacterial pathogens in severe infections.
    • Suggests potential treatment strategies based on antimicrobial susceptibility.
    • Underscores the zoonotic potential of certain gram-negative bacteria.

    More Related Videos

    A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model06:02

    A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

    Published on: November 6, 2020

    Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice14:10

    Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

    Published on: July 29, 2022

    Related Concept Videos

    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Rocky Mountain Spotted Fever01:26

    Rocky Mountain Spotted Fever

    Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
    Bacterial Meningitis01:24

    Bacterial Meningitis

    Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
    Diphtheria01:28

    Diphtheria

    Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
    Bacterial Meningitis II: Pathophysiology01:26

    Bacterial Meningitis II: Pathophysiology

    Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...