Gene-by-Sleep Duration Interaction for Glycemic Traits in More Than 480,000 Individuals
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Updated: Oct 31, 2026

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Heming Wang1,2, Pavithra Nagarajan1, Clint L Miller3,4
1Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Article Highlights:
The biological mechanisms of how sleep duration impacts type 2 diabetes pathogenesis and glycemic control are unclear. This study reveals 16 loci (11 novel) that interact with either short or long sleep duration to influence hemoglobin A1c, fasting glucose, or fasting insulin. Short and long sleep duration loci were nonoverlapping. Regulation of copper and diacylglycerol levels appear as distinct cellular mechanisms implicated by long and short sleep duration loci, respectively. Identified gene targets present insight for potential type 2 diabetes therapeutic design approaches related to JIP1-c-Jun N-terminal kinase interaction disruption, pericyte health, N-methyl-d-aspartate receptor activity, anti-inflammatory and leptin-enhancing dietary supplements, and serpins.
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