Comparative Analysis of GFR Measurement Techniques: Part 1. Concepts and Endogenous GFR Markers
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Updated: Oct 31, 2026

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Clayton T Brady1,2,3, John C Lieske1,3,4, Kianoush Kashani1,3,5
1Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Abstract:
The GFR is a key indicator of kidney function, yet no ideal method exists for its direct measurement. This two-part review examines the development of GFR measurement techniques, focusing on their physiologic basis, performance characteristics, and clinical applications. Part 1 reviews endogenous markers used to eGFR, including creatinine-based and cystatin C-based equations, with emphasis on their derivation, limitations, and clinical use. Part 2 addresses exogenous filtration markers and measured GFR methodologies, highlighting comparative performance and specific uses. Emphasis is placed on innovation in marker development, highlighting the need for continued development and standardization to enhance accuracy and clinical utility.
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