A consistency criterion for EQ-5D-5L bolt-on valuation
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Published on: November 1, 2018
Michał Jakubczyk1, Fanni Rencz2,3, Kim Rand4,5
1SGH Warsaw School of Economics, Warszawa, Poland. michal.jakubczyk@sgh.waw.pl.
Objective:
EuroQol is developing the EQ-5D Bolt-on Toolbox, an experimental set of bolt-ons designed to improve the sensitivity of EQ-5D-5L in specific populations. For use in cost-utility analyses, EQ-5D-5L+bolt-on value sets should be consistent with EQ-5D-5L value sets. This study proposes a method to define and maintain such consistency and examines its properties.
Methods:
We developed a novel contraction method that defines consistency using the distribution of disutilities in measurement data and estimates a contraction parameter from the conditional distribution of bolt-on levels given the core EQ-5D-5L profile to account for information overlap. The method was tested for nine bolt-ons: breathing, cognition, hearing, self-confidence, skin irritation, sleep, social relationships, tiredness, and vision. We used general-population samples from 14 countries, with 10,395-42,206 observations per bolt-on, and patient samples from six disease areas, with 312-2,486 observations. Core-dimension disutilities were based on the UK EQ-5D-5L value set, and bolt-on disutilities were taken from published studies. Associations of the contraction parameter with bolt-on disutilities and core-dimension correlations were assessed using linear regression.
Results:
Achieving consistency required contraction factors ranging from 0.871 for breathing to 0.989 for sleep. Stronger contraction was required for bolt-ons with larger disutilities and for those more strongly correlated with the core dimensions, although only the former association was statistically significant.
Conclusion:
The contraction method aligns EQ-5D-5L+bolt-on value sets with EQ-5D-5L value sets, reducing potential double counting while preserving the increased sensitivity provided by bolt-ons.
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