Quality control trials of prothrombin time: an assessment of the performance in serial studies

A series of collaborative exercises on the one-stage prothrombin time test involving hospitals in Britain and overseas was performed between 1972 and 1977. The British Comparative Thromboplastin (BCT) and the lyophilised test plasmas were issued from the National (UK) Reference Laboratory for Anticoagulant Reagents and Control. Participants were asked to test the plasma samples with the BCT using the recommended technique. Variability of performance was assessed by the 'index of reliability' based on the plasma variance and error variance within each exercise. The results show that hospitals have attained higher precision in the later trials.