Organophotocatalytic radical relay for distal C(sp3)-H lactonization of unactivated alkenes
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Updated: Oct 31, 2026

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
Published on: April 22, 2016
Koustav Pal1, Manasi Mallick1, Shirshendu Giri1
1Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur-741246, West Bengal, India. suresh@iiserkol.ac.in.
Abstract:
We report a green and atom-economical strategy for distal lactonization, enabling the efficient construction of structurally diverse lactone frameworks under mild conditions. This protocol employs a low loading of a metal-free photocatalyst to enable distal Csp3-H activation at the C6 and C11 sites via the 1,5-HAT process, thereby avoiding the use of stoichiometric reagents and minimizing hazardous waste generation. Notably, the reaction proceeds with high regioselectivity at distal C6 and C11 positions, offering a valuable platform for site-selective molecular editing.
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