Euphabeones A-D, Rearranged Jatrophane Diterpenoids from Euphorbia hylonoma: Isolation, Structural Elucidation, and Anti-Senescence Evaluation
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Updated: Oct 31, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Shu-Qi Wu1, Xian-Yuan Yang1, Peng-Cheng Huang1
1Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong510006, People's Republic of China.
Abstract:
Euphabeones A-D (1-4), four rearranged jatrophane diterpenoids, were isolated from Euphorbia hylonoma. 1 and 2 possess a new 1(15→14),13(14→15)-diabeo-jatrophane skeleton featuring a 16-oxatricyclo[11.2.1.01,11]hexadecane core, while 3 and 4 are rare 1(15→14)-abeo-jatrophanes. Their structures were established by spectroscopic analysis, ECD calculation, and single-crystal X-ray diffraction. A plausible biosynthetic pathway for 1-4 was proposed and supported by biomimetic skeletal conversion. Compound 2 exhibited potent antisenescence activity, effectively ameliorating senescence phenotypes both in vitro and in vivo.
